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KMID : 0377619640070060751
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Korean Jungang Medical Journal
1964 Volume.7 No. 6 p.751 ~ p.754
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Pathology of congenital syphilis associated with adrenal cytomegaly
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池堤根/Chi, Je Gun
李尙國/崔奎淞/朴孃實/任元一/Lee, Sang Kook/Choi, Kyu Song/Park, Yang Sil/Im, Won Il
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Abstract
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Pathologic-anatomic and pathologic-histologic studies were made on one autopsy case of congenital syphilis which waas serologrcally confirmed in maternal and cord blood, being accompanied with adrenal cyomegalia. Microscopical findinfs are principally composed of diffuse visceral fibrosis and widespread extramedullary hemopoiesis. Visceral fibrosis was most severe in the liver and pancreas, although spleen, lungs, kidneys and adrenal glands are also involved.
Hear shows a focal hematopoietic lesion.
Thymus cintains many foci of Dubois abscess.
Liver is characterized by extensive periportal and intralobular connective tissue increase and laso extensive hematopoietic foci. The fibrotic change is more marked in right lobe especially around ductus venusus. Giant cell transformation of hepatic cells is also prominent.
Lungs are enlarged and uniformly firm. In teralveolar septa show diffuse connective tissue increase and mononuclear cell infiltration.
spleen is enlarged and also shows connective tissue proloferatin and numerous macrophages in between the splenic sinusoids.
Adrenal gands are slighty thickended in capsular structure and the connective tissue increase is focally extended inward between the cords of cells of the permanent cortex.
The fetal portion of the cortex shows a widespread change in the size, shape and nuclear pattern of its constituent cells. The cells are polyhedral measuring up to 45μ in diameter, and structures resembling inclusions are present.
Brain shows syphilitic leptomenimgitis.
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